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10‑vial kitLongevityRetaNord MOTS-c research peptide — 10-vial kit
MDP Mitochondrial peptide

MOTS-c

Mitochondrial-derived peptide · 10-vial research kit

Mitochondrial-derived peptide

MOTS-c is a mitochondrial-derived peptide (MDP) — a short peptide encoded within mitochondrial DNA — studied for its role in cellular metabolism and mitochondrial signalling.

€33910 mg · 10-vial kitIn stock
Vial size
Kit size

Both kit sizes ship within the EU — free shipping either way.

Plain, unbranded packaging. No product names, no logos — nothing on the outside indicating what is inside. Tracked to a DPD Locker or your address.

Guaranteed delivery. If your order doesn't reach you, we ship it again free — lost, damaged or stolen.

Purity 99%+ HPLC
Kit 10 or 30 vials
Ships in 24–48h

For laboratory and in vitro research use only. Not for human or veterinary use, and not for use in diagnostic procedures.

EU-stocked & shippedDispatched in 24–48hFree shipping10 or 30-vial kitsSealed, lyophilized vials

About MOTS-c

MOTS-c is a 16–amino-acid peptide encoded within the mitochondrial genome. As one of the first-described mitochondrial-derived peptides, it is studied in metabolic and mitochondrial-signalling research. RetaNord supplies it as a lyophilized 10-vial kit.

RetaNord supplies MOTS-c as fixed kits of 10 or 30 lyophilized vials, each verified at 99%+ identity purity by independent third-party HPLC (Janoshik), and every kit ships with a lot-specific Certificate of Analysis. Supplied for laboratory and in vitro research use only.

How MOTS-c works

MOTS-c is a 16–amino-acid peptide encoded inside the mitochondrial genome, within the 12S rRNA gene — one of the first mitochondrial-derived peptides to be described. Published work associates it with AMPK signalling and with the folate–methionine cycle.

Unusually for a peptide of its size, it has been reported to move to the nucleus under metabolic stress, where the literature describes it influencing nuclear gene expression. That mitochondria-to-nucleus direction is what makes it a distinct research tool rather than another receptor ligand.

Mechanistic summary drawn from published literature, provided for research context only. Not a therapeutic claim.

What the research shows

The founding 2015 Cell Metabolism paper characterised MOTS-c and its metabolic effects in animal models; a 2023 review in Frontiers in Endocrinology collects the work published since.

Research interest sits in mitochondrial signalling, insulin sensitivity and exercise biology. The literature is preclinical — there is no approved medicine containing MOTS-c anywhere.

An educational summary of published literature. It is not a claim about any outcome for any buyer, and RetaNord supplies this compound for laboratory research use only.

Storage & handling

Sealed, lyophilized vials. 2–8 °C for routine storage; −20 °C or below for long-term. Room temperature is for transit and handling only — it is not a storage state for a peptide.

Once reconstituted. Keep at 2–8 °C and never freeze — ice crystals cause irreversible damage. Reconstituted with bacteriostatic water (0.9% benzyl alcohol) a vial is commonly used within about 30 days; with plain sterile water, within 24–48 hours.

Keep vials sealed and protected from light, and minimise freeze–thaw cycles of frozen stock — each cycle costs potency.

Work out concentration and draw volume in the reconstitution calculator →

Specifications

CategoryLongevity & Cellular Energy
Compound classMitochondrial-derived peptide
Presentation10 vials per kit · lyophilized
Available sizes10 · 40 mg per vial
CAS number1627580-64-6
Molecular formulaC101H152N28O22S2
Molecular weight≈ 2175 g/mol
Physical formSterile-filtered, freeze-dried
Identity purity99%+ (HPLC)
Independent testingJanoshik · third-party HPLC
Storage2–8°C; −20°C long term
DocumentationLot-specific Certificate of Analysis
MOTS-c Certificate of AnalysisCertificate of Analysis — batch VX733554Independent third-party testing by Janoshik · HPLC purity 99.552% and content verified.View the full report →

References & research

Selected peer-reviewed literature via PubMed, provided for educational context. A reference does not imply a clinical claim for RetaNord products.

  1. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
  2. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

MOTS-c — questions

Do the kits come with a Certificate of Analysis?

Yes — every kit ships with a lot-specific third-party Certificate of Analysis: independent HPLC purity and content testing by Janoshik, with the batch matching your vials. View the current CoA.

What is a mitochondrial-derived peptide?

It is a short peptide encoded by mitochondrial DNA rather than the nucleus. MOTS-c is among the best-studied examples and is used as a research tool in metabolism studies.

Why is this sold as a 10-vial kit?

These research compounds are supplied in fixed kits of 10 identical vials — the standard research quantity. One kit (10 vials) is the minimum order to the EU.

How should MOTS-c be stored?

Sealed lyophilized vials keep at 2–8 °C, or −20 °C for long-term storage. Once reconstituted, keep refrigerated and never freeze it. See storage & handling for the full detail.

How do I work out the concentration?

The volume of bacteriostatic water you add sets the concentration — the vial size alone does not. Enter your vial size and diluent volume in the reconstitution calculator to calculate the concentration for your assay.

Is MOTS-c an approved medicine anywhere?

No. The published literature is preclinical, and no regulator has approved a medicine containing MOTS-c. That is what “research use only” means here — the studies are not finished.

Documented peptides, shipped from the EU.

Every RetaNord kit ships within 24–48 hours, discreetly packaged and tracked. All kits ship within the EU. For laboratory research use only.

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